Committed to Science, Committed to Health
As someone interested in supplements, nutraceuticals, and overall human heath, you require science-backed solutions. You have a commitment to improving the health and wellness of your customers. You’re not satisfied with just getting by—you want to help create lasting results that make an impact in people’s lives. At Mineral Logic, we share this same commitment to science and passion for better health, and it drives our mission every day. We understand that what sets us apart from other ingredient suppliers isn't only providing groundbreaking advancements in the industry; it's also keeping our products rooted firmly in sound scientific research. We confidently promise evidence-based quality assurance when crafting solutions tailored to your specific needs. That way, you can always feel secure knowing your consumers are receiving leading edge products only proven through rigorous investigation and clinical trials — quality supplements they can trust!
One paper that includes our resident scientist, Dr. Mark K. Williams, was published in December of 2022. Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA).
The abstract for your review
Triple-negative breast cancer (TNBC) is associated with high mortality due to the high expression of pro-inflammatory cytokines and lack of targeted therapies. N-acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase that promotes inflammatory responses through the deactivation of Palmitoylethanolamide (PEA), an endogenous bioactive lipid mediator. Here, we examined NAAA expression in TNBC cells (MDA-MB-231 and MDA-MB-BrM2 cells) and the effects of NAAA inhibition on TNBC tumor growth, using a selective NAAA inhibitor AM11095 (IC50 = 20 nM). TNBC cells expressed elevated levels of full-length and splice mRNAs NAAA variants. TNBC cells also express the N-acyl ethanol amides and elevated levels of the two fatty acid cores arachidonic (AA) and docosahexaenoic (DHA). PEA or AM11095 inhibited the secretion of IL-6 and IL-8, reduced the activation of the NF-kB pathway, decreased the expression of VEGF and Placental growth factor (PLGF) in TNBCs, and inhibited tumor cell migration in vitro. Using cellular magnetic resonance imaging (MRI), body images of mice administered with human MDA-MB-BrM2 cells treated with AM11095 showed a significant decrease in tumor numbers with a lower volume of tumors and increased mice survival. Mice untreated or treated with vehicle control showed a high number of tumors with high volumes in multiple organs. Thus, NAAA inhibition may constitute a potential therapeutic approach in the management of TNBC-associated inflammation and tumor growth.
To view a pdf of the study, click below.
Whether your products fall under the categories of nutraceutical, beverage, functional food, or body-care, MLG-50 fulvic acid may very well be the supplement to set you apart, to truly assist you with helping your customers reach optimal health.
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Disclaimer: Our fulvic products are for supporting overall health by way of supplying minerals, trace minerals, antioxidants, electrolytes, and other micro-nutrients. Our products are NOT meant for the treatment mitigation or prevention of any disease or health ailments.