Peer-Reviewed Validation for MLG-50 and MLG-A50:Integrated Safety, Inflammation Modulation, Regenerative Support, and Microbiome Activity

Published in Scientific Reports, this study confirms that Mineral Logic’s fulvic acid formulations demonstrate strong cytocompatibility, absence of appreciable genotoxicity, anti-inflammatory pathway support, regenerative potential, and selective probiotic-stimulating activity across in vitro and in vivo models.

Read the published paper → https://rdcu.be/e3OXq

Executive Summary

Mineral Logic is proud to announce the publication of a peer-reviewed scientific study in Scientific Reports evaluating our fulvic acid formulations, MLG-50 and MLG-A50.

The research, conducted in collaboration with the University of Lodz and Mineral Logic scientists, provides integrated safety and microbiota profiling across multiple experimental models. The findings demonstrate:

• High cytocompatibility across mammalian cell types

• No appreciable genotoxicity

• Support for balanced inflammatory signaling

• Pro-regenerative activity in cellular wound models

• Selective stimulation of beneficial gut bacteria

• Increased microbial diversity in vivo

These results reinforce what innovative formulators already require: documented safety, measurable bioactivity, and mechanism-level insight.

For R&D leaders, functional food developers, beauty chemists, and clean-label strategists, this publication provides peer-reviewed validation that fulvic acid can be both clean-label and scientifically substantiated.

This is not marketing language. It is published data.

Key Findings

1. Strong Cytocompatibility and Favorable Safety Profile

• High compatibility across multiple mammalian cell types

• No relevant nuclear abnormalities detected

• Genotoxicity levels are significantly lower than reference dietary compounds

These results support structure–function positioning, such as:

“Supports normal cellular health” and “Provides ingredients that help maintain healthy cellular function.” 

2. Support for Balanced Inflammatory Pathways

• Suppression of NF-κB activation in LPS-stimulated monocytes

• Reduced secretion of TNF and IL-6

• Preservation of IL-10 production

The data demonstrate support for balanced immune and inflammatory responses without impairing pro-resolution pathways.

Compliant positioning includes:

“Supports a healthy immune response”

“Helps maintain balanced inflammatory processes.” 

3. Regenerative Potential in Cellular Models

• MLG-A50 significantly accelerated wound closure in LoVo cell models

• MLG-50 supported early-phase regenerative responses

• Activity consistent with antioxidant and anti-inflammatory mechanisms

Appropriate compliant positioning:

“Supports the body’s natural tissue-repair processes.” 

4. Selective Probiotic-Stimulating Activity

In vitro:

• Significant stimulation of Lactobacillus rhamnosus and Lactobacillus plantarum

• Activity observed at dilutions as high as 1/32,768

• Neutral or inhibitory activity toward E. coli and Salmonella paratyphi

In vivo (guinea pig model):

• Increased gut microbial diversity

• Enrichment of beneficial taxa associated with mucosal integrity and immune modulation

Compliant positioning:

“Supports a healthy gut microbiome.”

“Promotes the growth of beneficial gut bacteria.” 

Conclusion

MLG-50 and MLG-A50 demonstrate:

• High cytocompatibility

• No appreciable genotoxicity

• Support for balanced immune signaling

• Pro-regenerative cellular activity

• Selective microbiome support in vitro and in vivo

This publication strengthens the scientific foundation of Mineral Logic’s fulvic complex and supports ongoing research, including a current collaboration with Dr. Karen Sweazea at Arizona State University, investigating clinical outcomes related to metabolic health.

Your next breakthrough starts 80 million years deep — and now it is peer-reviewed.